OMNIDASE - Hyaluronidase for Injection

Description Omnidase is a purified and standardised preparation of the enzyme Hyaluronidase in the form of a sterile, freeze-dried powder. Each ampoule contains 1,500 IU of Hyaluronidase Pharmacology Site and Mode of Action Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. Indications As an aid to local anaesthesia in ophthalmology Contraindications Hypersensitivity to hyaluronidase. Precautions Do not apply directly to the cornea. Use in Pregnancy As there are no adequate and well-controlled studies conducted with Omnidase, it should be avoided in pregnancy. Use in Lactation It is not known whether the drug enters breast milk. Caution should be exercised in administering it to breast-feeding mothers. Precautions Use only if the container is undamaged.  Carcinogenesis: Studies in animals to evaluate the carcinogenic potential have not been conducted.  Pregnancy: Category C. There are no adequate and well-controlled studies in pregnant women. Carbodol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.  Nursing mothers: It is not known if this medication is excreted in breast milk. Exercise caution when administering to a nursing woman.  Pediatric Use: Safety and efficacy in pediatric patients have not been established.  Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.  Adverse Effects Allergic reactions have included rare reports of orbital and / or periorbital edema and / or periorbital inflammation occurring with the use of hyaluronidase in conjunction with local anaesthetics in ophthalmology. Eye disorders such as conjunctival edema (chemosis) and / or conjunctival inflammation, restricted eye movements, decreased visual acuity, blurred vision and exophthalmos (proptosis) have been reported. Local irritation, infection, bleeding and bruising occur rarely. Dosage & Administration Aid in the diffusion of local anaesthetic in ophthalmology, As per Ophthalmologist’s requirement Storage Store in cool & dark place. Presentation Omnidase is available in a pack of 10 Vials.