CARBODOL - Carbachol 0.01% Solution

Composition   Each ml contains   Carbachol U.S.P. 0.01% w\v Water for injection q.s Dosage form Solution Category Anti Miotic Indications Carbachol is used during ophthalmic surgery to constrict the pupil during cataract surgery. In addition, it reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery.  Contraindications Use of carbachol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. The parasympathomimetic action of this drug will exacerbate the symptoms of these disorders.It should not be used in those persons showing hypersensitivity to any of the components of this preparation.  Dosage & Administration Aseptically remove the sterile ampoule from the package by and keep the ampoule into a sterile tray. Withdraw the contents into a dry sterile syringe, and replace the needle with an atraumatic cannula prior to intraocular instillation. Not more than one-half milliliter should be gently instilled into the anterior chamber for the production of satisfactory miosis. It may be instilled before or after securing sutures. Miosis is usually maximal within two to five minutes after application. Side Effects Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction have been reported.  Warnings For single-dose intraocular use only. Discard unused portion.  Intraocular carbachol 0.01 % should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease.  Precautions Use only if the container is undamaged.  Carcinogenesis: Studies in animals to evaluate the carcinogenic potential have not been conducted.  Pregnancy: Category C. There are no adequate and well-controlled studies in pregnant women. Carbodol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.  Nursing mothers: It is not known if this medication is excreted in breast milk. Exercise caution when administering to a nursing woman.  Pediatric Use: Safety and efficacy in pediatric patients have not been established.  Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.  Storage Store in cool & dark place. Presentation Carbodol is available in ampoule - a pack of 5 x 1ml.