Indicated in the following groups of patients.

1. Patients with surgically confirmed Otosclerosis which has shown progressive sensorineural deafness disproportionate with age.
2. Patients with pure sensorineural deafness whose family history, age of onset, audiometric pattern and good auditory discrimination indicate the possibility of cochlear Otosclerosis.
3. Patients with radiological demonstration by polytomography of spongiotic changes in the cochlear capsule.
4. Patients with positive Schwartz sign- (reddish-blue discoloration behind the tympanic membrane) occasionally seen in Otosclerosis. It is present when the Otosclerosis is active when there is increased blood flow to support the new bone growth)
5. Pre-operative administration.  If there is progression of the cochlear component of hearing loss, fluoride therapy is given before operation.
6. Post operative treatment

1. Patients with chronic nephritis with nitrogen retention.
2. Patient, with chronic rheumatoid arthritis there may be an increase of the joint symptoms during treatment which subside after cessation.
3. Pregnant or lactating women.
4. In children before skeletal growth end been achieved. 5. Allergic to fluoride with induces itching rash